Emerging biotechnologies have captured the imagination, interest, and concerns of the world. Scenarios once relegated to science fiction movies and novels are now potentially within the grasp of bioengineering. The purposeful design of biology can enable novel ways to meet a variety of societal needs—from the biomanufacturing of commodities to gene therapies and the recreation of once-extinct organisms. This biological revolution, or “bioeconomy,” has the potential to address important issues such as climate change, sustainable energy, and food production, as well as improved medicines and quality of life for all. But with this capability comes dual use (that is, not only for commercial/military use but also by good actors/bad actors) as well as profound ethical concerns, making The Genesis Machine a timely volume.