It is now widely recognized that terrorists may inflict great trauma upon us by using biological weapons against America’s civilian populations. There is, however, no common perception of how this problem should be defined and countered. In the language of today’s business consultants, neither the “problem space” nor “the solution space” has been well mapped. In military terms, we have no established a method of focusing our efforts, testing alternative strategies, setting requirements, and determining priorities. This paper is designed to show how we can do these things.